54gene Statistical Geneticist Jobs in Nigeria

54gene Statistical Geneticist Jobs in Nigeria


Job Description

  • The Statistical Geneticist will have an opportunity to make his or her mark within a growing scientific team within 54gene.

  • S/he will support the research discovery and development activities to transform human genetics and genomics discoveries to therapeutic hypotheses, and effectively communicate results to impact our emerging pipeline.

  • The successful candidate will have the opportunity to work in a fast-paced and highly collaborative environment and will be responsible for developing and employing rigorous statistical and computational approaches.

  • S/he will demonstrate experience in genotype-phenotype associations as well as engage fellow scientists and project teams to leverage genomics data in achieving project objectives.

    Roles and Responsibilities

  • Apply and develop robust statistical and computational approaches to analyze whole-exome and whole-genome sequence data in combination with phenotypic or other genomic data to enable disease/target/biomarker identification and evaluation, exploring mechanism of action, and identification of genetic causal links to disease or subtypes of disease

  • Evaluate and implement statistical methods to integrate, summarize and report genetic, genomic, and other omics data, examples include WGS, WES, GWAS, and RNA-seq

  • Understand strategies and methods for genotype imputation, haplotyping, relationship inference and/or polygenic risk score estimation

  • Work collaboratively within a diverse team, and provide learning opportunities for other staff, if and when applicable

    Qualifications

    Knowledge, Skills & Abilities

  • Knowledge of genome-wide analyses and approaches, including quality control options for genomic data, approaches for association analysis in the presence of relatedness or population structure, and approaches for burden-based analyses

  • Expertise with modern cluster and cloud computing environments and with statistical analysis software (R environment for statistical computing, STATA) and human genetics analysis tools (METAL, GCTA, PLINK or similar)

  • Ability to learn in a fast-paced work environment

  • Ability to coordinate and manage tasks and processes with minimal supervision

  • Strong sense of responsibility with keen attention to details

  • Good communication skills

    Education & Certifications

  • M.S or PhD in Biostatistics, Statistical Genetics, Computational Biology, or related field

  • 3+ years’ experience in biostatistics or statistical analysis
    of DNA sequencing data

    Experience

  • Knowledge and expertise with whole genome as well as whole exome sequence analysis

  • Solid foundation in statistical genetics principles and applications, especially population genetics

  • Demonstrated experience in statistical programming using R and other programming
    languages (e.g. Python, C/C++, Javascript) on large datasets

  • Experience designing and analyzing validation experiments for laboratory assays

  • Effective at communicating insights and presenting concepts to a diverse audience

  • Ability to work with multidisciplinary teams; Experience collaborating with lab scientists on data generation and analysis

  • Ability to annotate and explore potential functions of identified variants with publicly available functional datasets or fine-mapping tools

  • Knowledge of rare variant validation using multiple technologies and publicly available resources

  • Experience in genome-wide (GWAS) and phenome-wide association studies, especially as they relate to implications in large multi-ethnic cohorts and analysis

    Other

  • Authorization to work in the Nigeria, the United States, and/or the United Kingdom

  • Must live in one of the locations listed above

  • Valid international travel documentation

  • Occasional domestic and international travel may be required

    How to Apply

    For more information and job application details, see; 54gene Statistical Geneticist Jobs in Nigeria

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