University of Hull - UK
We are looking for a highly motivated PhD student to join our research group in the Department of Biological Sciences, University of Hull, Kingston upon Hull, United Kingdom.
Main focus of our research group is the identification and functional characterisation of mitochondrial and peroxisomal (glycosomal) metabolite transporters from the human pathogen Trypanosoma brucei.
This protozoan parasite is the causative agent of "sleeping disease", and is endemic in Sub-Saharan Africa. The results of our work will contribute to a better understanding of the unique and remarkable energy metabolism of this parasite, and will hopefully result in the development of novel, more effective drugs for treatment of the disease. The PhD project consists basically of two major research lines: A. A proteomics (mass-spectrometry) approach in which we will determine the complete proteome of mitochondrial membranes, isolated from different life-cycle stages of Trypanosoma brucei. Interesting metabolite carriers will be functionally characterised. B. Functional characterisation of a selected subset of previously identified mitochondrial carrier family (MCF) proteins by using a wide range of sophisticated molecular, biochemical, and cell biological tools. Candidates for the PhD position should have a Diploma/Masters degree or equivalent and ideally should have experience in molecular, biochemical or cellular biology work.
The PhD studentship is available from September, for the duration of 3 years.
The payment is according to the guidelines of the University of Hull.
Candidates should send their application (including CV and two referees) to: Dr Frank Voncken, Lecturer in Microbiology, Department of Biological Sciences, University of Hull, Hull, HU6 7RX, United Kingdom.
Closing date for application: 10 September