PhD Positions in Mass Spectrometry - Switzerland

(Biochemistry/Biotechnology/Bioinformatics/Ion Physics)

Institute of Chemical Sciences and Engineering, Switzerland

The Mass Spectrometry Laboratory at the Department of Chemical Sciences and Engineering at Swiss Federal Institute of Technology in Lausanne (EPFL), Switzerland, has been recently created with the goal to conduct fundamental and applied research in the area of biochemistry, analytical chemistry and biophysics with ultra-high performance mass spectrometry (including FT-ICR MS).

Particular focus is made on proteomics method and technique development.

The collaboration with Proteomics Core Facility, Life Science Department, Biochemistry Department and associated research institutes at the EPFL is highly encouraged. Currently, we are inviting applications for 3 Ph.D. student positions;

  • Ph.D. position in Biophysical Chemistry:

    Method development and application in structural analysis and identification of peptides, proteins and protein complexes by mass spectrometry.

    The main research directions will include gas-phase and solution phase top-down and bottom-up protein structural analysis, post-translational modification identification, mapping of protein surfaces and protein-ligand interaction sites.

  • Ph.D. position in Bioinformatics/Biophysical Chemistry:

    Improved peptide and protein structural analysis by biostatistics and database supported computer analysis of mass spectrometry data.

    Initial project step will be focused on software development for automatic prediction of tandem mass spectrometry data with its further development into automated de novo peptide and protein primary and secondary structural analysis tool and improved protein identification in database searches.

  • Ph.D. position in Analytical Biotechnology/Ion Physics:

    Improved peptide and protein structural analysis by instrumental advances in mass spectrometry.

    Particularly, development and implementation of electron injection systems for ion-electron interaction in FT-ICR MS to increase the efficiency of electron capture dissociation (ECD) and associated techniques.

  • Requirements:

  • M.Sc. in biochemistry, molecular biotechnology, analytical chemistry, physical chemistry, technical physics or related discipline.
  • Practical experience in the field of mass spectrometry and/or protein handling is an advantage.
  • Computer knowledge preferably include programming skills, experience with ion/electron optics calculations is an advantage.
  • Candidates should be proficient in English (speaking and writing).

    Application should include a CV, list of publications, names and contacts of 2-3 references, list of research interests.

    For applications and further information please contact:

    Professor Yury O. Tsybin
    EPFL SB ISIC UPTSY BCH 4312 (Bâtiment de chimie UNIL) CH-1015 Lausanne


  • Scholarship 2017/18

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